Oxidative Stress Disease And Cancer

Author: Keshav K Singh
Publisher: World Scientific
ISBN: 1783260114
Size: 10.95 MB
Format: PDF, ePub, Mobi
View: 5332

This book aims to provide a comprehensive review of the most up-to-date knowledge of the sources and molecular mechanisms of oxidative stress, and its role in disease and cancer. It also focuses on the novel agents and methods that can be employed to prevent oxidative stress and associated diseases. The authors first review the most recent data on the basic mechanisms of oxidative stress. The second section discusses oxidative stress leading to several diseases and cancers, and in the third section, the strategies employed in the prevention and treatment of oxidative stress-related diseases are discussed. Contents:Yin and Yang of Mitochondrial ROS (A Starkov & K B Wallace)Intracellular Oxidative Stress Caused by Ionizing Radiation (H J Majima et al.)Oxidative Damage to Mitochondria (J C Tilak & T P A Devasagayam)Oxidative Stress and Antioxidant Defenses in Plants (O Blokhina & K Fagerstedt)Lipid- and Protein-Mediated Oxidative Damage to DNA (M D Evans & M S Cooke)Oxidative Damage to Nucleotide: Consequences and Preventive Mechanisms (Y Nakatsu & M Sekiguchi)Oxidative Damage to DNA and Its Repair (L J Rasmussen)Cellular Responses to Reactive Oxygen Species (I W Dawes)Oxidative Stress, Cell Proliferation, and Apoptosis (J S Carew et al.)Oxidative Damage to Carbohydrates and Amino Acids (M d'Ischia et al.)Superoxide Dismutase 2 Deficient Mice: The Role of Increased Reactive Oxygen Species in Genomic Instability (E Samper et al.)Oxidative Stress, Genetic Variation, and Disease (L Lyrenäs et al.)Oxidative Stress and Autoimmune Diseases (J Saegusa et al.)Does Oxidative Stress Determine Lifespan? (F L Muller & H Van Remmen)Oxidative Stress and Ataxia–Telangiectasia (E M Dunner & D J Watters)Oxidative Stress and Cardiovascular Disease (S Johar et al.)Oxidative Stress, Insulin Resistance, and Cardiovascular Disease (A Ceriello)Pathogenesis and Etiology of Down's Syndrome in Relation to Oxidative Stress (S Arbuzova & H Cuckle)Oxidative Stress and Ulcerative Colitis: Experimental Evidence and Implications for Treatment (D N Seril et al.)Oxidative Stress and Neurodegenerative Disease (K Schüssel et al.)Oxidative Stress and Mitochondrial Disease (C-Y Lu et al.)Oxidative Stress and Respiratory Disease (R Maselli & G Pelaia)Oxidative Stress and Human Reproduction (A Agarwal & S Allamaneni)Oxidative Stress and Multistage Carcinogenesis (P C Goswami & K K Singh)Oxidative Stress and Cancer Cachexia (G Mantovani & C Madeddu)Oxidative Stress in Cancer-Prone Diseases (G Pagano)Iron-Induced Carcinogenesis (S Toyokuni)Copper and Carcinogenesis (T Theophanides & J Anastassopoulou)Arsenic, Oxidative Stress, and Carcinogenesis (M F Hughes & K T Kitchin)Estrogen-Induced Carcinogenesis: Importance of Oxidative Stress (H K Bhat)Oxidative Stress in HIV Infection (W Dröge)Oxidative Stress and Breast Cancer (J Ahn & C B Ambrosone)Oxidative Stress and Photocarcinogenesis: Strategies for Prevention (S K Katiyar)Oxidative Stress and Coenzyme Q10 Therapy (F L Rosenfeldt et al.)Plant-Derived Antioxidants (F H Sarker & Y Li)Oxidative Stress and Cancer Therapy (K Pong)Nanoscale Antioxidant Therapeutics (T Dziubla et al.)Use of Biomarkers of Oxidative Stress in Human Studies (C-Y Chen & J B Blumberg) Readership: Academics, researchers, scientists, clinicians, physicians, members of the society for free radical biology and medicine and members of SFRR. Key Features:The first book that describes the roles of oxidative stress in diseasesOver 35 of the leading experts in the oxidative stress field have contributed to this book. Their expertise ranges from basic to translational to therapeutic aspects of oxidative stress-associated diseasesKeywords:Oxidative Stress;Disease;Cancer;Free Radical;Superoxide;Mitochondria;Aging;Antioxidant;Antioxidant Therapy

Cancer Stress And Death

Author: Stacey B. Day
Publisher: Springer Science & Business Media
ISBN: 1475795734
Size: 72.88 MB
Format: PDF, ePub, Mobi
View: 1879

This book has been well received in many places and in many countries. It was awarded a ranking in the top ten publications on behavioral medicine in the year that it first appeared. When, in 1977, we began to fit the components of Cancer, Stress, and Death together, the established medical view was that each subject repre sented a different discipline, and that to integrate fields so diverse in information content was to seek to achieve a synthesis beyond reasonable limits. Had we been required to concern ourselves with the knowledge of each component in its entirety, this might have been so, but our concern, of course, was to integrate only those items of knowledge in any one field that could bear upon the field of interest of another. Moreover, we were concerned that physi cians and scientists take account of the inner forces that shape motivation and individual behavior, as well as the cultural identity of individuals, and we hoped that the biopsychosocial way in which we believed would gain ground and win support. Now, with need for a second edition, one can hardly conceive of not bringing together diverse contributions in one volume. Such syntheses as we have made clearly confirm that one can arrive at several levels of understanding of human situations through wise integration of biological paradigms within various social, cultural, and psychological parameters-which essentially is a simple way of defining the biopsychosocial way.

Stress Et Cancer Du Sein

Author: Henri JOYEUX
Publisher: Editions du Rocher
ISBN: 2268004147
Size: 75.63 MB
Format: PDF, ePub, Mobi
View: 5886

Le stress. présent au quotidien dans notre existence trépidante, est-il un facteur causal du cancer du sein ? Doit-on l'incriminer comme facteur déterminant ou, au contraire, vérifie-t-on que le stress peut aussi protéger de ce fléau ? Quelles que soient les conclusions qui s'imposent après lecture de ces pages, le stress nous accompagne dans la vie et donc dans la maladie ; de l'annonce d'une tumeur, moment terrible, à sa gestion quotidienne, cet ouvrage nous aidera à assumer de manière éclairée. Nous découvrirons une des 10 causes du cancer du sein, le stress, qui nous est, au premier abord si évidente. une réalité qu'il faut apprendre à gérer en douceur avec le minimum de traitements. Enfin, l'auteur nous propose pour une prévention active du cancer du sein et de ses récidives, un arsenal de 9 solutions, dont certaines seront aussi déterminantes pour une gestion raisonnée quand se déclenche la maladie. Un questionnaire pratique basé sur une longue expérience clinique et sur les dernières découvertes de la Science est à votre disposition. Il vous permettra d'évaluer vos facteurs risque" de cancer du sein, de mieux comprendre ses causes si vous en avez été victime mais encore d'établir une échelle de probabilités d'éventuelles rechutes et ainsi de les éviter ! Un livre pour toutes les femmes qui veulent prévenir le cancer du sein ou une récidive, pour tous les psychologues confrontés à des patientes stressées qui ont besoin d'être écoutées et apaisées."

Inflammation Oxidative Stress And Cancer

Author: Ah-Ng Tony Kong
Publisher: CRC Press
ISBN: 1466503718
Size: 10.72 MB
Format: PDF, ePub, Mobi
View: 5826

Increasing scientific evidence suggests that the majority of diseases including cancer are driven by oxidative stress and inflammation, attributed to environmental factors. These factors either drive genetic mutations or epigenetically modify expression of key regulatory genes. These changes can occur as early as gestational fetal development, and major questions remain as to how dietary/nutritional phytochemical factors biochemically interact with such genetic and epigenetic events. With chapters written by international experts, Inflammation, Oxidative Stress, and Cancer: Dietary Approaches for Cancer Prevention examines the latest developments on the effects of various dietary phytochemicals. Divided into nine sections, the book begins with the basic mechanisms of inflammation/oxidative stress-driven cancer, including an overview of the topic and how to prevent carcinogenesis, the role of obesity in inflammation and cancer, and antioxidant properties of some common dietary phytochemicals. Subsequent sections cover cellular signal transduction, molecular targets, and biomarkers of dietary cancer-preventive phytochemicals, as well as their potential challenges with in vivo absorption and pharmacokinetics. The chapters also examine the cancer-preventive properties of various classes of phytochemicals, including vitamins A, D, and E; omega-3 and omega-6 fatty acids; flavanoids and polyphenols; garlic organosulfur compounds and cruciferous glucosinolates; and selenium, traditional Chinese herbal medicines, and alpha lipoic acid. The final section of the book explores the latest developments on the interactions of dietary phytochemicals through epigenetics and the management of chronic inflammation with nutritional phytochemicals.

Role Of Capsaicin In Oxidative Stress And Cancer

Author: Sanjay K. Srivastava
Publisher: Springer Science & Business Media
ISBN: 9400763174
Size: 72.45 MB
Format: PDF, ePub, Mobi
View: 1958

This book describes the mechanism of the anti-cancer effects of capsaicin including the involvement of cytochrome P-450 in the bioactivation; identification of mitochondria as the key target site for oxidative stress; involvement of mitochondrial respiratory chain in the production of ROS; prevention of chemically-induced carcinogenesis, discussion on TRPV-1 receptor mediated or independent anti-cancer effects; identification of p53 activation as a possible mechanism; involvement of Cox-2 in apoptosis, suppression of transcription factors such as NF-kB and STAT-3; inhibition of cell survival pathways including PI3K/Akt and the involvement of intrinsic mitochondrial cell death pathway.

Oxidative Stress In Cancer Biology And Therapy

Author: Douglas R. Spitz
Publisher: Springer Science & Business Media
ISBN: 9781617793974
Size: 68.18 MB
Format: PDF, Kindle
View: 368

During the last 30 years it has become clearly evident that oxidative stress and free radical biology play key roles in carcinogenesis, cancer progression, cancer therapy, and normal tissue damage that limits treatment efficacy during cancer therapy. These mechanistic observations have led to the realization that free radical biology and cancer biology are two integrally related fields of investigation that can greatly benefit from cross fertilization of theoretical constructs. The current volume of scientific papers was assembled under the heading of Oxidative Stress in Cancer Biology and Therapy in order to stimulate the discussion of how the knowledge gained in the emerging field of oxidative stress in cancer biology can be utilized to more effectively design interventions to enhance therapeutic responses while causing fewer treatment limiting complications. The chapters contained in this volume provide highly informative emerging perspectives on how that selective enhancement of oxidative stress in cancerous tissues can be used as a target for enhancing therapeutic outcomes as well as how selective inhibition of oxidative stress could spare normal tissue damage and inhibit carcinogenesis. In this regard, the book represents an outstanding resource for both basic and translational scientists as well as clinicians interested in the field of oxidative stress and cancer therapy.

Oxidative Stress In Cancer Aids And Neurodegenerative Diseases

Author: Luc Montagnier
Publisher: CRC Press
ISBN: 9781420002928
Size: 50.57 MB
Format: PDF, Kindle
View: 978

Based on a conference on Oxidative Stress and Redox Regulation, held at the Pasteur Institute, Paris, this work examines fundamental, chemical, biological and medical studies of free radicals on different targets and the consequences of their reactivity. It covers the chemistry and biochemistry of free radicals, free radicals as second messengers that group the activation of transcription factors and enzymes, the importance of the antioxidant system in cell metabolism regulation, and the role of free radicals and antioxidants in disease management. The editors of this work are three of the most respected pioneers in the field. Dr. Montagnier is credited as the discoverer of HIV.

Cancer Stress And Death

Author: Stacey B. Day
Publisher: Springer Science & Business Media
ISBN: 1475795734
Size: 53.55 MB
Format: PDF
View: 5848

This book has been well received in many places and in many countries. It was awarded a ranking in the top ten publications on behavioral medicine in the year that it first appeared. When, in 1977, we began to fit the components of Cancer, Stress, and Death together, the established medical view was that each subject repre sented a different discipline, and that to integrate fields so diverse in information content was to seek to achieve a synthesis beyond reasonable limits. Had we been required to concern ourselves with the knowledge of each component in its entirety, this might have been so, but our concern, of course, was to integrate only those items of knowledge in any one field that could bear upon the field of interest of another. Moreover, we were concerned that physi cians and scientists take account of the inner forces that shape motivation and individual behavior, as well as the cultural identity of individuals, and we hoped that the biopsychosocial way in which we believed would gain ground and win support. Now, with need for a second edition, one can hardly conceive of not bringing together diverse contributions in one volume. Such syntheses as we have made clearly confirm that one can arrive at several levels of understanding of human situations through wise integration of biological paradigms within various social, cultural, and psychological parameters-which essentially is a simple way of defining the biopsychosocial way.

Commuting Stress

Author: Meni Koslowsky
Publisher: Springer Science & Business Media
ISBN: 1475797656
Size: 20.54 MB
Format: PDF
View: 3874

Several people have asked what motivated us to write a book about commut ing, something that we all do but over which we have very little control. As a matter of fact, the general reaction from professional colleagues and friends alike was first a sort of knowing smile followed by some story. Everyone has a story about a personal commuting experience. Whether it was a problem with a delayed bus, a late arrival, broken-down automobiles, hot trains or subways, during the past year we have heard it all. Many of these stories must be apocryphal because, if they were all true, it is amazing that anyone ever arrived at work on time, at home, or at some other destination. The interest for us likely stems from many factors that over the years have probably influenced our thinking. All of the authors studied and/or grew up in the New York City metropolitan area. For illustration, let's devote a few paragraphs to describing some of the senior author's (Koslowsky's) life experiences. As a young man in New York City, he was a constant user of the New York City subway system. The whole network was and still is quite impressive. For a relatively small sum, one can spend the whole day and night in an underground world (growing up in New York often makes one think that the whole world is contained in its five boroughs).

Stress Response Pathways In Cancer

Author: Georg Wondrak
Publisher: Springer
ISBN: 9401794219
Size: 47.17 MB
Format: PDF, ePub
View: 4761

It is now established that dysregulated cell stress response pathways play a critical role in tumorigenesis, and a refined mechanistic understanding of this phenomenon at the molecular level promises to open new avenues for targeted therapeutic strategies that may benefit cancer patients in the near future. Coauthored by recognized leaders in cancer research from five continents, this novel book provides a comprehensive perspective on cell stress response pathways and therapeutic opportunities. Focusing on the role of genotoxic, proteotoxic, oxidative, metabolic, and inflammatory stress in tumorigenesis, the book is essential reading for students, basic researchers, and biomedical health care professionals interested in cancer and therapeutic development.